Pyruvatkinasedefizienz (PK) - West Highland White Terrier Diversität Dogs with two copies of

Dogs with two copies of HPS3 mutation have a slightly darker coat color and lighter eyes than the TYRP1 related brown dogs

because of degeneration of photoreceptor cells in the retina

Es ist gekennzeichnet durch eine Störung der neuromuskulären Übertragung

which can damage the optic nerve and cause vision loss

Allerdings werden nicht alle Hunde mit den Varianten DCM entwickeln

Pyruvatkinasedefizienz (PK) - West Highland White Terrier Diversität Dogs with two copies ofCanine pyruvate kinase deficiency (PK deficiency) is an autosomal recessive disorder of cardiovascular system. Pyruvate kinase (PK) is essential for glycolysis in erythrocytes, which deliver oxygen to tissues. PK deficiency results in erythrocytes with decreased energy, in such ATP needed for energy cannot be synthesized, and cellular death occurs. The symptoms occur between 4 months and 1 year of age and include severe haemolytic anaemia,