Leukozyten Adhäsionsdefizienz Typ III (LAD3) Katzen Clinical signs in Leonberger vary

Clinical signs in Leonberger vary greatly and have different age of onset from <1 year to 10 years of age

the severity of which requires euthanasia at about 1

Heterozygotie-Wert: Zeigt

This often leads to chronic kidney failure and shortened life span

incoordination of voluntary movements (ataxia)

Leukozyten Adhäsionsdefizienz Typ III (LAD3) Katzen Clinical signs in Leonberger varyLeukocyte adhesion deficiency (LAD3) is a rare canine autosomal recessive disorder characterised by failure of activation of beta 13 type integrins, expressed on haematopoietic cells. That results in bleeding diathesis, while leukocyte count remains normal. The symptoms start to show at around 6 months of age and include abnormal bleeding, dental disease, pyrexia, lameness and infections, such as deep pyoderma, pododermatitis, gingivitis and