Musladin-Lueke-Syndrom (MLS) ISAG delayed onset of developmental milestones

delayed onset of developmental milestones such as eye opening and tooth eruption

Mutation: TNR gene

die bei mehreren Hunderassen bekannt ist

goiter and dyshormonogenesis

Mutation: HACE1 gene

Musladin-Lueke-Syndrom (MLS) ISAG delayed onset of developmental milestonesMusladin Lueke Syndrome (MLS) is a hereditary disorder in Beagle dogs that affects the development and structure of connective tissue and manifests with extensive fibrosis of the skin and joints. The syndrome is multi systemic and is involved in defects of multiple organs and tissues, including bone, heart, skin, and muscle. Current evidence suggests that dogs that have two copies of the mutant gene are affected with MLS, making the sindrom a