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The extracellular N-terminus contains key regions involved in ligand recognition and binding

To evaluate the nature of the ASPL-VCP interaction, we used a combination of fluorescence-detected sedimentation velocity analytical ultracentrifugation (FDS-SV-AUC) and interference SV-AUC experiments with a 1:84 ratio of ASPL to VCP monomers [0.2 M Alexa Fluor 488 (AF488)ASPL to 16.8 M VCP] to approximate physiological conditions

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Increased thirst, urination, or persistent nausea could reflect inadequate diabetes control

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Nicotinamide riboside supplementation exerts an anti-obesity effect and prevents inflammation and fibrosis in white adipose tissue of female diet-induced obesity mice