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FIGURE 1 Estrogens play a multifaceted role in the central nervous system (CNS), influencing synaptic plasticity, neuronal development, and survival in newly formed spinal synapses, as well as promoting neural stem cell proliferation and maintaining the integrity of the blood-brain barrier (McCullough et al., 2003

Mol Cell Pediatr 13 , 18 (2026)

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2) insulin resistance leading to decreased glucose uptake by peripheral tissues (muscle and adipose)

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