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In combination with metformin immediate-release, sitagliptin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo with metformin immediate-release (Table 10)

Hansoh Pharma will receive an upfront payment of $112 million and is eligible to receive up to $1.9 billion in milestone payments associated with the development, regulatory approval and commercialization of the candidate, as well as royalties on sales

The preclinical evidence base for each component is substantial

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Thus, targeting immune pathways represents a promising strategy to suppress ferroptosis-mediated neurodegeneration

Clinical trials would be required to establish appropriate, safe, and effective dosing protocols for any human application of this compound