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The primary consequence of the enzymatic block is greatly reduced intracellular glutathione levels, usually less than 10% of normal levels

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First, glutathione helps to maintain proper levels of cytokines, including mitigating pro-inflammatory cytokines like TNF-a and IL-6, so everything stays balanced

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Angiopep-2, the ligand of the low-density lipoprotein receptor-related protein enhanced the BBB transcytosis of star-shaped, multibranched poly(l-glutamic acid) nanoconjugates in animals [50]