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Pharmacokinetics: Cyanocobalamin is administered intranasally, orally, and parenterally, while hydroxocobalamin is administered only parenterally. Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12. The bone marrow also stores a significant amount of the absorbed vitamin B12. This vitamin crosses the placenta and is distributed into breast milk. Enterohepatic recirculation conserves systemic stores. The half-life is about 6 days (400 days in the liver). Elimination is primarily through the bile; however, excess cyanocobalamin is excreted unchanged in the urine

This means that the entire 1mL syringe volume now holds 5,000mcg

Ashley makes this one every couple of weeks, and once you try it you'll understand why

It is especially beneficial for obese pets and those with dilated cardiomyopathy (DCM)

Journal of Dietary Supplements, 18 (1), 116

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