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That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

Not for Human or Veterinary Use.

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Published human trials report minimal adverse events at doses ranging from 50mg to 100mg daily over 12 weeks, with the most common findings being mild gastrointestinal discomfort (812% of participants) and transient headache (57%)

Clinical Markers for Treatment Effectiveness We watch for signs of success by checking clinical markers