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In pregnant rabbits given 0.2, 2, 22, 156, or 260 mcg/kg/day exenatide during fetal organogenesis, irregular fetal skeletal ossifications were observed at 2 mcg/kg/day, a dose yielding systemic exposure up to 12-times the human exposure from the MRHD of BYETTA based on AUC comparison
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Notably, this weight loss was sustained throughout the 68 week study period
There's also a dedicated support program for people taking weight-loss medications like GLP-1s, helping manage side effects and preserve muscle mass
Domestically synthesized peptides are subject to more stringent oversight regarding purity and trifluoroacetic acid (TFA) removal
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