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Side effects are not common but may include: Mild gastrointestinal upset (especially if this is the first time supplementation has been started) Loose stools or diarrhoea at higher doses Greenish discoloration of urine (harmless - temporary) These side effects usually end themselves within a few days as the dog's system adjusts
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On the gastrointestinal front, literature has described mucosal barrier protection via modulation of endogenous prostaglandin (PGE2) and heat shock proteins (HSP70/90)
The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks
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G., Vernacotola, S., Mariotti, P., Bianchi, E., Calvani, M., De Gaetano, A., Chiurazzi, P., and Neri, G
