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There were 41 genes uniquely overlapping at least 1 MS lesion type and LPC MOLs at demyelination, including genes with roles in neuroprotection ( GDNF ) and lipid metabolism and cholesterol trafficking ( APOE ), glutamatergic and axon-glial ephrin signaling genes ( GRM8, EPHA4 ), interferon signaling and MHC-I regulation ( IRF1, NLRC5 ) and ECM and cell adhesion molecules ( TNR , CNTN3 , ITGA8 )
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Freezing reconstituted peptides causes ice crystal formation that ruptures protein structures
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