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Patients who experience gastrointestinal side effects or have reduced kidney function may be better suited to alternative agents like DPP4 inhibitors, GLP1s, or SGLT2s

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Patients were classified as SCD when they presented to the memory clinic with cognitive complaint initiation, but no impairment in cognitive test performances and activities of daily living were observed 23

Therefore, it can be applied directly as a topical (graft washing), oral supplement, subcutaneous/intravenous injection, or a combination of multiple routes (similar to the approach applied in our study)