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That means, on average, they lost weight

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Bassett EW et al

The major enzyme superfamilies comprise cytochrome P450 monooxygenases (P450s), glutathione S-transferases (GSTs), carboxylesterases (COEs), ATP-binding cassette (ABC) transporters, and UDP-glycosyltransferases (UGTs) [5, 26, 36-39] (Figure 2)

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While results may develop more gradually than with some aggressive treatments, the improvements tend to be more sustainable and come without the risk of long-term damage or irritation that can accompany harsher approaches