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[10] For mood disorders like bipolar depression, clinical research has experimented with doses ranging from 15 mg daily (which demonstrated antidepressant effects in small studies) up to 200-300 mg daily in divided doses for refractory cases
10.1105/tpc.104.022608 5 BirkJ.MeyerM.AllerI.HansenH
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Nevertheless, once you have learned and practiced administering vitamin B12 injections, it will be easy to do it regularly at home
