References: (1) Gentinetta, S., et al
This is the first study to demonstrate that ASK1-p38/JNK regulated LD growth by promoting DGAT2 and GPAT4 targeting to the surface of LDs
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We also attempted replication analysis in the UK Biobank cohort, although the available data predate the availability of semaglutide or tirzepatide, and hence relied on earlier variants of GLP1 receptor agonists
155 However, whether this can be extrapolated to other CMRFs, and whether there is a pharmacoeconomic imperative, needs further clarification