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Some participants experience rapid initial weight loss in the first 812 weeks, while others show steady, gradual decline

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Figure 1 Although previous studies have demonstrated that GLP-1 has positive effects on attenuating neuropathology, its function and specific actions in CNS diseases have not been reviewed comprehensively

One study explored mechanistic associations between GLP-1 functioning and mood disorders in humans: a post-mortem investigation showed that, compared with healthy controls, patients who had been diagnosed with mood disorders had lower expression of the gene encoding for GLP-1R in the dorso-lateral prefrontal cortex and the hippocampus, whereas this association was not observed in the brain tissue of people with schizophrenia 176

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The challenge is that the proportion of chromosomally normal eggs decreases with age, which is why older women may need more IVF cycles to find a healthy embryo