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The enzyme catalyzes the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl-L-methionine (SAM) as a cofactor, producing 1-methylnicotinamide (1-MNA) as a metabolic byproduct

There is no universal recommendation, and the choice should ideally be guided by clinical assessment and, where appropriate, laboratory testing

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Digestive issues such as Crohn's or celiac disease can lead to impaired absorption of nutrients in the gut which may result in the need for B12 supplementation

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