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Mutation of these lysine residues to arginine (R) reduced TRIM28 ubiquitination in HEK293T cells, especially when the mutations were combined (K774R + K779R) (Fig
Moreover, selenium-containing chrysin, as a compound with anticancer and antioxidant effects, shows an antitumor effect in many ovarian cancer cell lines, and its inhibitory effect is achieved by inhibiting the expression of CBS and promoting the transformation of GSH (101)
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