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Therefore, the potential effects on offspring when metformin is used by pregnant females with PCOS should be thoroughly evaluated ( 3.3.1 Effect of metformin on early pregnancy in patients with polycystic ovary syndrome Patients with PCOS may be at a heightened risk of experiencing miscarriages during the early stages of pregnancy

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Additionally, they impact the occurrence and severity of nearly all chronic and degenerative diseases, encompassing cancer, atherosclerosis, stroke, arthritis, diabetes, osteoporosis, neurodegenerative conditions, inflammatory diseases, and skin disorders (Gaboon, 2011)

10, 2009, pp

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Optimal dosing is still being refined