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Bourgeois JP, Rakic P (1993) Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage

These intracellular modifications can also indirectly (epigenetically) alter cell behaviours 6,10 and, worse, cause apoptosis 11

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When combined with 5-Amino-1MQ, which inhibits NNMT (nicotinamide N-methyltransferase) to preserve NAD+ pools, the two compounds target overlapping but mechanistically distinct pathways