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The evidence base consists primarily of preclinical studies in animal models, with limited clinical data in humans
In yeast, Ohsumis and Klionskys laboratories first identified that ATG32 acts as the mitophagy-specific receptor, which directly interacts with the selective autophagy adaptor ATG8 via an ATG8-interacting motif (AIM) and ATG11 to form the nascent autophagosome (Okamoto et al., 2009)
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However, it is unclear to what extent the in vitro observations correspond to metabolic and disease processes seen in vivo 12
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