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The statement is the first to provide recommendations for perioperative management of patients taking GLP-1 RAs based on an in-depth systematic literature review of both clinical perioperative studies and gastric emptying data, Adriana Oprea, MD, the first author of the document, and her colleagues wrote

It reduces post-injury fibrosis by modulating the expression of matrix metalloproteinases (MMPs), promotes the formation of new blood vessels, and stimulates muscle fiber regeneration

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Third, individual variation is substantial: patients with severe insulin resistance or significant mitochondrial dysfunction may respond at lower doses than metabolically healthy athletes