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Providers are increasingly seeing side effects such as: Nausea, vomiting, and delayed gastric emptying Fatigue and muscle loss during rapid weight loss Micronutrient depletion from reduced food intake Emotional dysregulation related to appetite and blood sugar swings Plateaus or weight regain after discontinuation Some patients also feel disconnected from their hunger cues or experience anxiety about long-term dependency on injections

New Guidance Reflects a Change in Thinking Recent national guidance from several medical societies now recommends a more tailored approach

However, the pain is typically temporary and can be managed with appropriate adjustments in dosage or activity level

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Building on the essential role of SLC25A45 in TML transport, the authors explored the structural basis for its mechanistic function

e , Left, volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from HEK293T cells expressing a sgRNA targeting intergenic region or sgRNA targeting SLC33A1