Both mazdutide and tirzepatide exhibit gastrointestinal side effects, such as nausea , diarrhea , and vomiting , which are common among GLP-1 receptor agonists
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The longer food remains in the stomach, the queasier the patient becomes
Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia 2, a condition that increases the risk for medullary thyroid cancer Routine monitoring with serum calcitonin or thyroid ultrasound is of uncertain value and will likely lead to many incidental findings and unnecessary procedures
Fatigue is a documented side effect of tirzepatide, particularly during the first 4 to 6 weeks of titration