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Most strikingly, multiple trials have now shown that GLP-1 agonists can lead to the resolution of MASH, a severe form of fatty liver disease, without worsening of liver fibrosis, which is a common adverse outcome seen with some current medications
Other trials investigate how retatrutide compares to drugs such as tirzepatide, which is already showing promise when paired with menopausal hormone therapy to achieve increased weight loss
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Also in kidney, localization of GLP-1 receptor is under investigation, but it is thought to be expressed in vascular smooth muscle cells and immune cells in kidney [43]
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