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Cisplatin is able to bind directly to the sulfhydryl groups of antioxidant enzymes in the cochlea, leading to the inactivation of the enzymes, and it also decreases the levels of glutathione and NADPH (Nicotinamide Adenine Dinucleotide Phosphate), both of which are essential for the activity of the enzyme glutathione peroxidase (Gndodu et al., 2019)
347 This was achieved by decreasing the expression of proinflammatory cytokines such as tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8)
Some common side effects of this medicine include joint pain, injection site reactions (such as pain, swelling, and redness) and leg cramps
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Fragmentation voltages/collision energy were optimized at 120 V/16 eV for carnitine, 90 V/14 eV for IS, respectively, for the best response of the transitions
Sheng C, Javed U, Gibbs M, Long C, Yin J, Qin B, Yuan Q (2018) Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis
