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Call your healthcare provider if you have any of these conditions: Acute kidney injury, which can result in dehydration due to nausea, vomiting, or diarrhea Acute gallbladder disease, such as gallstones (solid, pebble-like deposits that form in the gallbladder) or inflammation of the gallbladder Acute pancreatitis, an inflammation of the pancreas that can cause severe stomach pain (that may spread to the back and can involve vomiting) Hypersensitivity reactions, such as anaphylaxis (a life-threatening allergic reaction) or angioedema (a buildup of fluid under the skin) Hypoglycemia (low blood sugar levels) Diabetic retinopathy complications (vision problems associated with diabetes that can lead to blindness) in people with type 2 diabetes Safety Warnings Both tirzepatide and semaglutide come with important safety precautions: The labeling for both tirzepatide and semaglutide carries boxed warnings (the FDAs strongest safety warning for prescription drugs) for an increased risk of thyroid tumors, including cancer

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