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2.2 Sample collection Blood was collected into EDTA, serum, and heparin tubes (Sarstedt AG & Co

The cell type or animal model, test concentrations, exposure time, sampling schedule, and assay method should be stated clearly

Considering that hepsin / mice have been reported to have dramatically reduced hepatic glycogen stores (Li et al

Additional mice (n = 3/group) were administered with MEDI4166 at 10 mg/kg or Ab#2.1_EX4 at 10 or 30 mg/kg to determine human Fc and GLP-1R active compound concentrations by taking blood samples at the following times post-dosing: 2 h, 4 h, 8 h, 1, 3, 7, 14 and 21 days

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These variants are associated with variation in GLP-1 receptor sensitivity and metabolic response, though genetic predisposition does not predict exact medication response or optimal dosing