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Semaglutide and Tirzepatide are available by prescription through Health Canada, though coverage varies by province and insurance plan

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Orthostatic considerations Orthostatic hypotension (a drop of 20 mmHg systolic or 10 mmHg diastolic on standing) can develop during early treatment for several reasons: Reduced fluid intake from nausea Reduced sodium intake from decreased eating Continued full-dose antihypertensive medications as BP drops Volume contraction from weight loss Patients should be counseled to rise slowly, maintain hydration, and contact their clinician if they experience dizziness on standing

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