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HT-induced ferroptosis elevates iron levels, lipid peroxidation (LPO) and reactive oxygen species (ROS), while decreasing glutathione (GSH) and mitochondrial membrane potential

Proton irradiation significantly reduces crypt viability, mucosal surface area, and cellular proliferation

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and a two-adult IV safety pilot at 10 mg and 20 mg (Lee, Walker & Ayadi, 2025)