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19 Designing around formulation patents Peptides are notoriously fragile
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During this time, the body is constantly adjusting to higher levels of the hormone
Gastrointestinal side effects such as diarrhoea are most common during the dose-escalation phase of retatrutide treatment and often improve or resolve once a stable maintenance dose is reached
The mechanisms behind GLP-1-related headaches are not fully understood, but likely involve changes in blood sugar levels (especially during early treatment when insulin sensitivity improves rapidly), dehydration from reduced fluid intake or GI losses, and the central nervous system effects of GLP-1 receptor activation, since GLP-1 receptors exist in the brain
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