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The Cochrans Q test and the MR Egger intercept test showed no evidence of significant heterogeneity or pleiotropy, which aligned with the core assumptions of MR
Semaglutide is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 due to preclinical findings of C-cell tumors in rodents[13]
56(2): p
GLP-1 works on multiple fronts: it enhances insulin secretion, inhibits glucagon production (reducing blood sugar), and delays gastric emptying, which leads to increased feelings of fullness (satiety)
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This can cause discontinuation of the medication
