Oxidation of the yeast mitochondrial thioredoxin promotes cell death
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The redox cycling enzymes thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GSH peroxidase, superoxide dismutase 1, and catalase, and several GSH S-transferases, which are the enzymes mediating the elimination of ROS, are all Nrf2 targets (242)
Factors like stress, poor diet, environmental toxins, and UV exposure can further deplete these levels, leading to signs of aging such as dull skin, brittle nails, and thinning hair