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Clusterin, a secreted chaperone upregulated by cellular stress and increasingly recognized as a putative exerciseresponsive factor, has been shown to protect human retinal microvascular endothelial cells (HRMECs) from VEGF- and AGE-induced hyperpermeability

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In addition, mitoTEMPO, a kind of mitochondria-targeted ROS scavenger, was utilized to identify this finding

Rarely reported side effects include: Allergic reactions, leading to a rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing