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This combination approach allows lower doses of each component, potentially reducing side effects while maintaining efficacy
10.1016/j.chom.2021.07.013 67 LiangL.LiuL.ZhouW.YangC.MaiG.LiH.et al (2022)
doi: 10.3390/antiox10050708 188
1997 Sexual Function Arousal Pathway Models Preclinical research using MTII as a non-selective MC agonist probe contributed to the discovery of melanocortin-mediated arousal pathways, eventually leading to the development of PT-141 (bremelanotide) as a more selective MC4R-focused compound
Its selectivity is therefore transporter-mediated and site-dependent, not receptor-subtype selectivity, and Mandrika et al
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