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Repeated-dose studies in rats, dogs, and mice for up to 6 weeks across various routes showed excellent tolerance with minimal adverse findings

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doi: 10.1371/journal.pone.0021827 277 ToK.CaoR.YegiazaryanA.OwensJ.NguyenT.SasaniniaK.et al

CBX3 protein levels were measured in various CRC cells using western blotting