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While more research is needed, the data hint at a potential protective effect on joint tissues themselves

Test days on which a rat failed to meet the FR10 criterion were excluded from primary analyses of %appropriate responding, but response rate data were retained to capture potential deficits in overall responding

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That is, TTFD prevents the gut paralysis induced by atropine or papaverine (23), while sulbutiamine promotes cholinergic neurotransmission, potentiating the action of ACh esterase inhibitors (215)