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The recommended concentration for IM injection is 1:1,000 (1 mg/ml), typically 0.01 mg/kg dose, up to 0.5 mg in adults

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DK substantially contributed to the design of the work, performed part of the drug administration and diabetic tests in studies 1 and 3 and part of the immunohistochemical and stereology analysis, and acquired/processed images

This slow titration is intentional and important