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People who have conditions that make absorption difficult are also good candidates for B12 shots
Choline - Enhances Fat Burning & Muscle Recovery: Supports fat metabolism and reduces muscle recovery time
Pernicious anemia is also treated with folic acid to help maintain red blood cells
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PMC 4962419
Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration
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