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Access this article Similar content being viewed by others Abbreviations CHEK2 gene: Checkpoint kinase DNA: Deoxyribonucleic Acid DIO: Iodothyronine deiodinases EFSec: Elongation factor of Sec GPx: Glutathione peroxidases MSRB1: Methionine-R-sulfoxide reductase 1 NIS: Sodium-iodide symporter PACAP: Pituitary adenylate cyclase-activating polypeptide PCR: Polymerase chain reaction PCR-RFLP: Polymerase chain reaction-restriction fragment length polymorphism Pax8: Paired box 8 ROS: Reactive oxygen species Selenium: Se Se-protein: Selenoprotein Sec: Selenocysteine SECIS: Selenocysteine-insertion sequence SBP2: SECIS Binding protein SELENOP1 or SePP1: Selenoprotein P1 SEPN1: Selenoprotein N SELENOS: Selenoprotein S SEPSECS: Selenocysteine synthase SNP: Single nucleotide polymorphism SEPHS2: Selenophosphate synthetase 2 TXNRD: Thioredoxin reductases TXNRD2: Thioredoxin reductase 2 T4: Thyroxine T3: Triiodothyronine TSH: Thyroid stimulating hormone TRAb: TSH receptor autoantibodies TPOAb: Antithyroperoxidase antibody TgAb: Antithyroglobulin antibodies ThyPRO: Thyroid patient-reported outcome TXNRD1: Thioredoxin/thioredoxin reductase-1 References Varlamova EG, Cheremushkina IV (2017) Contribution of mammalian selenocysteine-containing proteins to carcinogenesis

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Unlike the combinatorial therapy of G-protein-coupled receptor-based peptide dual agonists, such as GLP-1/glucagon, these peptidyl nuclear hormone conjugates require additional consideration for differential pharmacodynamics where time action for clearance of each activity is inherently dissimilar

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