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There are also case reports of serious psychiatric episodes appearing within weeks of starting treatment

Diabetologia 53 , 730740 (2010)

Effects on vasculature Vasoprotective actions against endothelial dysfunction and atherosclerosis Endothelial dysfunction, characterized by impaired vasomotility and an increase in pro-coagulant and pro-inflammatory mediators, is a key feature of T2DM [83]