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Whether the effects are meant to be localized or systemic will further shape these dosing decisions
Purpose: Measure mitochondrial oxidative status in liver Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells.The journal of toxicological.2012;37:1065-1069
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This sulfur-containing group allows glutathione to act as an electron donor
Lai Y, Gao FF, Ge RT, Liu R, Ma S, Liu X (2024) Metal ions overloading and cell death
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