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CJC1295 overcomes this limitation through two key structural innovations: first, the substitution of four amino acids that are primary DPP-IV cleavage sites, conferring intrinsic resistance to enzymatic degradation

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This delayed transit contributes to increased satiety and reduced appetitethe primary weight loss mechanism

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They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)

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