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Reconstitute: Add 3.0 mL bacteriostatic water ~ 3.33 mg/mL total concentration (1.67 mg/mL each peptide)

Previous studies have shown that selective depletion of synovial macrophages during experimental OA largely reduces cartilage damage and osteophyte formation, which are two major hallmarks of OA 48

These brain cells rely on glycolysis in energy generation and produce lactate, which serves as both main energy fuel and a signaling molecule for neurons

The supernatant was isolated by centrifugation at 65,000 g for 30 min and incubated with amylose resin (New England Bio-Labs) for 2 h at 4C

These include lifestyle modification requirements (69%), trialing lower-cost medications first (63%) and limiting therapy duration (63%)

N Engl J Med, 375:311-322