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Figure 8 8.2 Nanoparticle-mediated ferroptosis Nanoparticles (NPs) exhibit outstanding efficacy in precise targeting through both active and passive mechanisms

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Disturbances in components in the p53/MDM2/IGF-1R network may cause IGF-1R upregulation and growth advantage for the cancer cell

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The team demonstrated that these derivatives had higher GST-inhibitory activity in comparison to unmodified EA when administered to acute myeloid leukemia parental cells (HL60)

TMQ0153 induces redox state alterations and depletes GSH/GSSG and NAD + /NADH levels We observed that TMQ0153 induced varying levels of ROS involvement in AML cell death (Fig