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To sum up, GLP-1 receptor agonists protect neurons through several pathways including the classic cAMP/PKA/CREB pathway, the PI3K/Akt pathway, controlling inflammation, and keeping mitochondria working as shown in Figure 1

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These neuropods synapse and thus establish direct connections with vagal afferents, enteric glia, and efferent fibers, releasing neurotransmitters such as glutamate

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With skyrocketing demand has come skyrocketing prices, however, and neither the demand for these prescriptions nor their price points appear likely to come down any time soon

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