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Animal models of drug-induced ARF are often established using the aminoglycoside antibiotic GN 32

The problem: very short half-life (~50 minutes) and 3 daily injections at meals , an extremely impractical regimen

Full names for all the enzymes and substrates are given in Additional File 1

The body manufactures its own glutathione through a highly regulated, two-step enzymatic process that occurs primarily in the cytosol of the cell

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(11) Elena M Khvatova, Victor N Samartzev, Pavel P Zagoskin, Igor A Prudchenko, and Inessa I Mikhaleva (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia Peptides, 2003 Feb, Volume 24 (Issue 2), Pages 307-11