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NGRA uses information from NAMs and conservative decision-making to protect human health, aligning with the way regulatory decision-making has been conducted using traditional approaches ( Inspired by the NGRA concepts applied to other safety areas, such as systemic toxicity (Middleton et al., 2022), skin sensitisation (Gilmour et al., 2020

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Any combination with supplements or medications must be assessed by a qualified healthcare professional to avoid serious risks including hypoglycaemia, gastrointestinal harm, and drug interactions

Semaglutide is a synthetic peptide analogue of human glucagon-like peptide-1 (GLP-1)

Subgroup analysis The subgroup analysis by Malkin S J P et al

doi:10.1006/cimm.1993.1168 Liang CM, Lee N, Cattell D, Liang SM (1989) Glutathione regulates interleukin-2 activity on cytotoxic T-cells