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STEP-4 documented partial weight regain over 48 weeks after participants switched from active drug to placebo

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Thus, we set out to determine, first, whether Kat6a +/ mice could be used as a model for ARTHS with respect to effects on histone acetylation and cognitive and social functions and, second, whether treatment aimed to increase histone acetylation levels might ameliorate any learning, memory, or social dysfunction that might be present

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Bupropion is an antidepressant also used for smoking cessation, while naltrexone is used to treat opioid and alcohol dependence